摘要
非酒精性脂肪性肝炎/非酒精性脂肪性肝病(NASH/NAFLD)已经逐渐发展成为西方发达国家肝细胞癌(HCC)的主要病因之一。不同于经典的肝炎-肝硬化-肝癌疾病演变过程,近40%的NAFLD相关HCC可不经历肝硬化直接进展为HCC,表明其可能有不同的发病机制。阐述了关于NAFLD相关HCC发病机制的最新研究进展。
Nonalcoholic steatohepatitis(NASH)/nonalcoholic fatty liver disease(NAFLD)has gradually become one of the main causes of hepatocellular carcinoma(HCC)in Western developed countries.Different from the typical evolution process of hepatitis,liver cirrhosis,and liver cancer,nearly 40%NAFLD patients can progress into HCC without experiencing liver cirrhosis,suggesting other mechanisms may play a role in this process.This article elaborates on the latest research advances in the pathogenesis of NAFLD-related HCC.
作者
罗燕
施军平
LUO Yan;SHI Junping(Department of Translational Medicine,The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China;Institute for Liver Disease and Metabolism,Hangzhou Normal University,Hangzhou 310015,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第6期1217-1220,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金(81570524)
浙江省自然科学基金(LQ17H070002)
杭州市科技计划项目(20170533B42)。
关键词
非酒精性脂肪性肝病
癌
肝细胞
肝硬化
代谢
细胞重新编程
non-alcoholic fatty liver disease
carcinoma,hepatocellular
liver cirrhosis
metabolism
cellular reprogramming
