肝巨噬细胞靶向治疗脂肪性肝病及相关肝癌的机遇与挑战

Hepatic macrophage-targeted therapy for fatty liver disease:Opportunities and challenges

肝巨噬细胞是天然免疫系统中的重要组分,在生理环境下识别、清除坏死或凋亡的细胞碎片、病原体、呈递抗原,参与适应性免疫及免疫监视;在病理状态下,激活的巨噬细胞产生和释放大量炎性因子和细胞因子,并募集其他免疫细胞到局部参与抗感染或组织修复,是脂肪性肝病的重要发病机制及疾病进展的关键因素。作为肝脏免疫细胞的重要组分,肝巨噬细胞因子在疾病发病机制中的核心作用、以及基于肝巨噬细胞的靶向治疗而受到关注。综述了肝巨噬细胞靶向治疗脂肪性肝病及其面临的挑战和机遇。

Hepatic macrophages are an important cell component in the natural immune system.In the physiological environment,they can recognize and eliminate necrotic or apoptotic cell fragments,pathogens,and presenting antigens and participate in adaptive immunity and immune surveillance,while in the pathological state,activated macrophages can produce and release a large number of inflammatory factors and cytokines and recruit other immune cells to participate in local anti-infection or tissue repair,and therefore,they are the key factor in the pathogenesis and progression of fatty liver disease.As an important component of hepatic immune cells,hepatic macrophages have attracted great attention due to its role in the pathogenesis of the disease and the hepatic macrophage-targeted therapy.This article reviews the challenges and opportunities in hepatic macrophage-targeted therapy for fatty liver disease.