乌司他丁联合肺泡灌洗对重症肺炎合并急性呼吸窘迫综合征患者肺功能的影响分析

Effect of ulinastatin combined with alveolar lavage on pulmonary function in patients with severe pneumonia and acute respiratory distress syndrome

目的分析乌司他丁联合肺泡灌洗对重症肺炎合并急性呼吸窘迫综合征患者肺功能的影响。方法随机选取2015年8月至2019年8月本院收治的重症肺炎合并急性呼吸窘迫综合征患者60例,随机分为研究组与对照组,各30例。对照组给予抗感染、化痰,氧疗包括各种呼吸支持技术等常规治疗,研究组在常规支持基础上使用静脉滴注乌司他丁联合肺泡灌洗治疗,统计分析两组患者的血清TNF-α、IL-6、IL-10、CRP水平、血气分析、肺功能指标。结果与治疗前比较,两组患者治疗后的血清TNF-α、IL-6、IL-10、CRP水平均降低且研究组低于对照组(P<0.05)。与治疗前比较,两组患者治疗后的PaO2、PaO2/FIO2水平均升高,且研究组高于对照组,两组PaCO2水平均降低且研究组低于对照组(P<0.05)。结论乌司他丁联合肺泡灌洗能够有效改善重症肺炎合并急性呼吸窘迫综合征患者肺功能。

Objective To analyze the effect of ulinastatin combined with alveolar lavage on pulmonary function in patients with severe pneumonia and acute respiratory distress syndrome.Methods 60 patients admitted to our hospital from August 2015 to August 2019 were randomly divided into study group and control group,with 30 cases in each group.The control group was given routine treatment such as anti infection,expectoration,oxygen therapy including various respiratory support techniques.The study group was treated by intravenous infusion of ulinastatin combined with alveolar lavage on the basis of routine support.The serum TNF-α,IL-6,IL-10,CRP levels,blood gas analysis and lung function indexes of the two groups were statistically analyzed.Results The levels of TNF-α,IL-6,IL-10 and CRP in the study group were significantly lower than those in the control group(P<0.05).The increase of PaO2,PaO2/FiO2 and the decrease of PaCO2 in the study group were significantly higher than those in the control group(P<0.05).Conclusion Ulinastatin combined with alveolar lavage can effectively improve the pulmonary function of patients with severe pneumonia and acute respiratory distress syndrome.