缬沙坦联合氢氯噻氢治疗高血压心脏病的临床疗效分析

Clinical analysis of valsartan combined with hydrochlorothiazide in the treatment of hypertensive heart disease

目的分析缬沙坦联合氢氯噻氢治疗高血压心脏病的临床效果。方法选取2017年3月至2018年3月到本院就诊的100例高血压心脏病患者作为研究对象,随机分为对照组与观察组,各50例。对照组采用缬沙坦进行治疗,观察组采用缬沙坦联合氢氯噻氢进行治疗,比较两组患者治疗后的治疗效果以及治疗前后的血压。结果对照组治疗总有效率为80%,显著低于观察组的92%,比较差异有统计学意义(P<0.05);对照组不良反应发生率为16%,高于观察组的2%,比较差异有统计学意义(P<0.05)。结论缬沙坦联合氢氯噻氢治疗高血压心脏病临床疗效显著,明显降低患者血压,不良反应发生率低,安全性高,可在临床广泛推广。

Objective To analyze the clinical effect of valsartan combined with hydrochlorothiazide in the treatment of hypertensive heart disease.Methods 100 patients with hypertension and heart disease who came to our hospital from March 2017 to March 2018 were selected as the subjects.The patients were randomly divided into the control group and the observation group,with 50 cases in each group.The control group was treated with valsartan,the observation group was treated with valsartan combined with hydrochlorothiazide,and the therapeutic effect and blood pressure before and after treatment were compared between the two groups.Results The total effective rate of treatment in the control group was 80%lower than that in the observation group(92%),and the difference was statistically significant(P<0.05).The incidence of adverse reactions 16%in the control group,was higher than that in the observation group(2%),and the difference was statistically significant(P<0.05).Conclusion Valsartan combined with hydrochlorothiazide is very effective in the treatment of hypertensive heart disease.It can significantly reduce the blood pressure of patients.The incidence of adverse reactions is low and the safety is high.Valsartan combined with hydrochlorothiam can be widely used in clinic.