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骨髓间充质干细胞移植治疗帕金森病的实验分析

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摘要 目的:探讨骨髓间充质干细胞移植治疗帕金森病机制和效果。方法:立体定位法单侧纹状体内双点注射6-羟多巴胺制备帕金森病模型大鼠,将5-溴脱氧尿嘧啶核苷标记的骨髓间充质干细胞移植到模型大鼠中,使用免疫组织化学以及免疫荧光检测酪氨酸羟化酶状况。结果:移植治疗后8周,30只大鼠平均旋转速度为(6.10±0.41)r/min,损毁侧纹状体内大量5-溴脱氧尿嘧啶核苷阳性细胞分布,并可见酪氨酸羟化酶阳性细胞明显增加。结论:骨髓间充质干细胞移植治疗帕金森病疗效明显,治疗机制可能是外源性酪氨酸羟化酶经分化神经元样细胞。
作者 花育旗 陈斌
出处 《科技成果纵横》 2020年第5期260-260,共1页
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