中长链脂肪酸结构脂对小鼠脂质代谢的影响

Effect of dietary medium-and long-chain triacylglycerols on lipid metabolism in mice

肥胖与慢性病风险增加密切相关。中长链脂肪酸结构脂已被公认为在防治肥胖方面具有很大的发展前景。本研究制备了3种不同中链脂肪酸含量(10%、20%、30%,w/w)的中长链脂肪酸结构脂,系统地研究了它们对C57BL/6J小鼠脂质代谢的影响。含有30%(w/w)中链脂肪酸的结构脂可以有效降低小鼠的体重,改善小鼠的脂代谢和肝脏甘油三酯水平,进一步发现其通过上调肝脏内基因蛋白过氧化物酶体增殖物激活受体α和长链酰基辅酶A脱氢酶表达提升脂肪酸β-氧化,且下调脂肪酸合成酶、乙酰辅酶A羧化酶1、固醇调节元件结合蛋白1c和苹果酸酶表达抑制脂肪酸合成。

Obesity is related to an increasing risk of chronic diseases.Medium-and long-chain triacylglycerols(MLCT)have been recognized as a promising choice to reduce body weight.In this research,three MLCT with different contents of medium-chain fatty acids(MCFA)(10%,20%,30%,w/w)were prepared,and their effects on lipid metabolism of C57BL/6J mice were systematically investigated.MLCT with 30%(w/w)MCFA can effectively reduce body weight,improve lipid metabolism and liver triacylglycerol level.The expression levels of genes encoding enzymes for fatty acid degradation increased markedly and expression levels of genes encoding enzymes for de novo fatty acid biosynthesis decreased significantly in the liver of mice treated with MLCT containing 30%(w/w)MCFA.