胶质瘤扩大切除术后神经功能及生命质量情况

Analysis of changes in neurological function and quality of life after extended resection of glioma

目的:探讨胶质瘤扩大切除对患者神经功能及生命质量的影响。方法:选取2016年1月-2018年1月在我院治疗的脑胶质瘤患者71例,根据最终选取的手术方案分为观察组(n=33)和对照组(n=38),观察组给予胶质瘤扩大切除术,对照组给予常规胶质瘤切除术,观察两组手术前后神经功能、语言功能及生命质量,同时随访两组生存时间。结果:观察组术后3个月NIHSS评分为(11.02±5.10)分,明显低于对照组(17.50±4.22)分,差异有统计学意义(P<0.05);观察组和对照组手术前后语言功能评分(ACE-R评分)差异无统计学意义(P<0.05);观察组术后3个月生命质量(EORTC QLQ-C30评分)为(73.02±9.53)分,明显高于对照组(62.30±8.91)分,差异有统计学意义(P<0.05);观察组和对照组中位总体生存时间差异无统计学意义(P>0.05)。结论:胶质瘤扩大切除术有较好的效果,有利于患者神经功能及生命质量的改善。

Objective:To investigate the effect of extended resection of glioma on neurological function and quality of life in patients.Methods:Seventy-one patients with glioma treated in our hospital from January 2016 to January 2018 were divided into the observation group(n=33)and the control group(n=38)according to the final selection procedure.The observation group were received extended resection of glioma,while the control group were received conventional glioma resection.The neurological function,language function and life quality of the two groups were observed before and after operation,and survival time of two groups were followed up.Results:The NIHSS score of the observation group at 3 months after operation was(11.02±5.10)scores,which was significantly lower than that of the control group(17.50±4.22)scores,and the difference was statistically significant(P<0.05).There was no statistically significant difference in language function score(ACE-R score)between the observation group and the control group before and after operation(P<0.05).The quality of life(EORTC QLQ-C30 score)of the observation group at 3 months after operation was(73.02±9.53)scores,which was significantly higher than that of the control group(62.30±8.91)scores,and the difference was statistically significant(P>0.05).There was no significant difference in median survival time between the observation group and the control group(P>0.05).Conclusion:Extended resection of glioma has a good effect,which is conducive to the improvement of neurological function and quality of life.