久坐行为与卵巢癌发病风险相关性的meta分析

Meta-analysis of relationship between sedentary behavior and risk of ovarian cancer

目的利用系统评价方法,综合评价久坐行为对卵巢癌患病风险的影响。方法计算机检索中国知网数据库(CNKI)、万方数据库、维普数据库、PubMed、Embase、The Cochrane Library,搜集截至2019年1月15日已发表于各数据库的关于久坐行为与卵巢癌发病关系的前瞻性队列研究,同时手工检索纳入文献的参考文献。由两位研究者根据纳入与排除标准筛选文献,并提取有效资料,运用Revman 5.3软件进行meta分析。结果本meta分析共纳入5篇前瞻性队列研究,共384 779名参与者,随访期间被诊断为卵巢癌的病例数为2 278例,结果显示久坐行为对卵巢癌的患病风险有一定的影响,且成正相关性,其差异有统计学意义(多因素校正:RR=1.55,95%CI:1.32~1.81,P<0.01)。结论目前的证据显示,久坐时间越长,卵巢癌的患病风险也越高。鉴于本研究的局限性,仅纳入5项研究,且存在较多的混杂因素,应进一步进行多中心、大样本、高质量的前瞻性队列研究进行验证。

Objective To evaluate the impact of sedentary behavior on the risk of ovarian cancer using a systematic review method.Methods China Knowledge Network database,Wanfang database,Weipu database,PubMed,Embase and Cochrane Library were searched for prospective cohort studies regarding the relationship between sedentary behavior and ovarian cancer published until January 15,2019;meanwhile,a hand search of the references of included articles was conducted.Two researchers screened the studies based on the inclusion and exclusion criteria,extracted valid data,and performed a meta-analysis using Revman 5.3 software.Results A total of 384,779 participants from 5 prospective cohort studies were included in this meta-analysis.The number of cases diagnosed with ovarian cancer during the follow-up was 2,278.The results showed that sedentary behavior had a certain impact on the risk of ovarian cancer,and there was a positive correlation between them,with a statistically significant difference(multi-factor correction:RR=1.55,95%CI=1.32-1.81,P<0.01).Conclusions Current evidence suggests that the longer sedentary behavior,the higher the risk of ovarian cancer.In view of the limitations of this analysis that only includes 5 studies with more confounding factors,further multi-center,large-sample and high-quality prospective cohort studies should be performed for validation.