中药在肺癌放射增敏中的作用研究进展

Research progress on radiosensitization effect of traditional Chinese medicine in lung cancer

肺癌是我国发病率和病死率最高的恶性肿瘤,放射治疗是其主要的治疗方式之一。如何提高放射治疗效果和完成率,减轻毒副反应,是当前面临的重要课题。近年来,越来越多的学者发现活血化瘀类、补益固本类和清热解毒类中药复方制剂,以及黄连素、10-羟基喜树碱等有效单体成分因具有多靶点、多途径、提高机体免疫力、安全性高等优势,逐渐显示出放射增敏剂的应用潜力。

Lung cancer is the most common cancer and has the largest proportion of all cancer-related deaths,while radiotherapy plays a key role in both curative and palliative treatments for lung cancer.The recent leading research is how to enhance the effect and completion of radiotherapy.More studies has indicated that some traditional Chinese medicine(TCM),such as huoxue huayu recipe,buyi guben recipe,qingre jiedu recipe,berberine,10-hydroxycamptothecin and so on,have multi-target,multi-pathway,improving immune function and relief to adverse reaction,which would be the potential radiosensitizers in treatment of lung cancer.The paper reviews the progress of traditional Chinese medicine in radiosensitivity of lung cancer.