miRNA对肿瘤微环境中免疫细胞的调控作用

Regulatory Role of MicroRNAs on Immune Cells in Tumor Microenvironment

微RNA(miRNA)是一类普遍存在于真核生物体内的非编码单链RNA,几乎参与机体所有的生理和病理过程,组织内miRNA的异常表达往往与疾病紧密相关。在肿瘤微环境中,免疫细胞以及肿瘤细胞表达的miRNA存在异常表达,这些miRNA能调控免疫细胞的分化、增殖、凋亡和功能等过程,从而影响肿瘤的发生和发展。肿瘤微环境对免疫应答的抑制是临床上肿瘤免疫治疗需要攻克的一大难题,探究肿瘤微环境中miRNA对免疫细胞的调控机制,可为肿瘤免疫治疗提供新靶点。

MicroRNA(miRNA)is a kind of non-coding single-stranded RNA,which is ubiquitous in eukaryotes and involved in almost all physiological and pathological processes of the body.The altered miRNA expression is often closely related to human diseases.Increasing evidence proved that miRNAs are abnormally expressed in tumor microenvironment.In the tumor microenvironment,miRNAs which are both expressed by immune cells and tumor cells adjust the immune response by regulating the differentiation,proliferation,apoptosis and function of immune cells,thus affecting the development of tumors.The inhibition of tumor microenvironment on immune response is a major obstacle to overcome in the clinical tumor immunotherapy,and the research of the regulation mechanism of miRNA on immune cells in tumor microenvironment makes the discovery of new targets for tumor immunotherapy possible.