维生素D3改善晚期肺癌化疗患者癌因性疲乏的研究

Study of vitamin D3 on improving cancer fatigue in patients with advanced lung cancer undergoing chemotherapy

目的观察维生素D3改善晚期肺癌化疗患者癌因性疲乏的临床应用效果。方法选取衢州市人民医院2018年2月至2019年2月收治的晚期肺癌化疗患者47例,采用随机数字表法分为对照组24例、观察组23例,两组患者按美国临床肿瘤学临床实践指南癌因性疲乏指南2017予支持治疗,观察组予维生素D3预防治疗。比较两组癌因性疲乏缓解情况及C反应蛋白(CRP)、红细胞沉降率(ESR)、白细胞介素6(IL-6)的变化情况。结果观察组癌因性疲乏缓解率为69.6%(16/23),高于对照组的29.2%(7/24),差异有统计学意义(χ2=7.837,P<0.05)。治疗后,观察组CRP、ESR、IL-6分别为(26.98±7.51)mg/L、(30.50±7.00)mm/h、(7.00±4.08)ng/L,均低于对照组的(41.02±6.63)mg/L、(33.25±4.34)mm/h、(10.75±4.57)ng/L,差异均有统计学意义(t=9.11、2.56、2.47,均P<0.05)。结论晚期肺癌患者化疗中预防使用维生素D3能改善癌因性疲乏,降低炎性因子水平。

Objective To study the clinical application effect of vitamin D3 on improving cancer fatigue in patients with advanced lung cancer undergoing chemotherapy,and to explore the mechanism and treatment of cancer fatigue.Methods From February 2018 to February 2019,47 patients with advanced lung cancer undergoing chemotherapy admitted in the People's Hospital of Quzhou were selected.The patients were divided into the control group(24 cases)and the observation group(23 cases)by the random number table method.The two groups were given supportive treatment according to the US clinical oncology clinical practice guidelines 2017 guidelines for cancer fatigue,and the observation group was given vitamin D3 preventive treatment.The remission of cancer fatigue and the changes of C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)and interleukin 6(IL-6)in the two groups were compared.Results The remission rate of cancer fatigue in the observation group was 69.6%(16/23),which was higher than that in the control group[29.2%(7/24)],the difference was statistically significant(χ2=7.837,P<0.05).After treatment,the levels of CRP,ESR and IL-6 in the observation group were(26.98±7.51)mg/L,(30.50±7.00)mm/h and(7.00±4.08)ng/L,respectively,which were lower than those in the control group[(41.02±6.63)mg/L,(33.25±4.34)mm/h and(10.75±4.57)ng/L],and the differences were statistically significant(t=9.11,2.56 and 2.47,all P<0.05).Conclusion The preventive use of vitamin D3 in chemotherapy for advanced lung cancer patients can improve cancer fatigue and reduce the level of inflammatory factors.