非那雄胺联合米诺地尔酊治疗男性雄激素性脱发52例疗效观察

Treatment of male androgenic alopecia with finasteride combined with minoxidil tincture:a clinical observation of 52 cases

目的探讨非那雄胺联合米诺地尔酊治疗男性雄激素性脱发的临床疗效。方法选取中国医科大学绍兴医院2018-2019年诊治的男性雄激素性脱发患者102例为研究对象,采用随机数字表法分为两组,对照组50例给予非那雄胺治疗,治疗组52例给予非那雄胺联合米诺地尔酊治疗,两组疗程均为6个月。比较两组治疗效果及不良反应发生情况。结果治疗组有效率为86.5%(45/52),显著高于对照组的66.0%(33/50)(χ2=4.93,P<0.05);治疗组不良反应发生率为3.8%(2/52),显著低于对照组的18.0%(9/50),差异有统计学意义(χ2=5.22,P<0.05)。结论非那雄胺联合米诺地尔酊治疗男性雄激素性脱发安全有效。

Objective To investigate the clinical efficacy of finasteride combined with 5%minoxidil in the treatment of male androgenetic alopecia.Methods A total of 102 males with androgenetic alopecia diagnosed and treated in Shaoxing Hospital of China Medical University during 2018-2019 were selected in the study and divided into two groups by random number table method.The control group(50 cases)was only given finasteride,and the treatment group(52 cases)was given finasteride combined with minoxidil.All the patients were treated for 6 months.The therapeutic effects and adverse reactions during the treatment were compared between the two groups.Results The effective rate of the treatment group was 86.5%(45/52),which was significantly higher than 66.0%(33/50)of the control group(χ2=4.93,P<0.05).The incidence of adverse reactions in the treatment group was 3.8%(2/52),which was significantly lower than 18.0%(9/50)in the control group(χ2=5.22,P<0.05).Conclusion Finasteride combined with 5%minoxidil is safe and effective in the treatment of male androgenetic alopecia,which is worthy of clinical promotion.