血府逐瘀汤联合心脉隆注射液对急性冠脉综合征患者经皮冠状动脉介入术后影响

Effect of Xuefu Zhuyu Decoction Combined with Xinmailong Injection on Patients with Acute Coronary Syndrome after PCI

目的探讨血府逐瘀汤联合心脉隆注射液对急性冠脉综合征患者经皮冠状动脉介入治疗(PCI)术后的血清N端-脑钠肽前体(NT-proBNP)、超敏肌钙蛋白(THS-TNT)等水平及心功能的影响。方法以河北省沧州中西医结合医院2017年7月-2018年12月行PCI术的200例急性冠脉综合征患者为对象,按电脑数字表法随机分为两组,每组各100例,对照组术后予以常规西医治疗,实验组于此基础上施予血府逐瘀汤联合心脉隆注射液治疗,对比两组NT-proBNP水平、THS-TNT水平、心功能、急性冠脉综合征积分及血小板功能。结果治疗后,实验组NT-proBNP(261.27±71.55)pg/mL、THS-TNT(8.30±1.61) pg/mL低于对照组(320.20±72.33)pg/mL及(17.29±2.70)pg/mL,差异有统计学意义(P<0.05);实验组左室舒张末内径(LVEDd)及左室收缩末内径(LVEDs)均短于对照组,而左室射血分数(LVEF)高于对照组,差异有统计学意义(P<0.05);实验组中医证候积分(6.00±1.57)分,血瘀积分(4.17±1.32)分,低于对照组(9.14±1.79)分及(7.80±1.82)分,差异有统计学意义(P<0.05);实验组6-酮-前列腺素F1α(6-keto-PGF1α)水平高于对照组,而血栓烷B2(TXB2)低于对照组,差异有统计学意义(P<0.05)。结论血府逐瘀汤联合心脉隆注射液有助于改善急性冠脉综合征患者PCI术后的NT-proBNP、THS-TNT水平及心功能,并且促使其急性冠脉综合征积分降低,改善血小板功能。

Objective To observe the effect of Xuefu Zhuyu Decoction combined with Xinmailong Injection on the patients with acute coronary syndrome after percutaneous coronary intervention(PCI)and its influences on the levels of N-Terminal pro-brain natriuretic peptide(NT-proBNP),high-sensitivity troponin T(THS-TNT)and cardiac function. Methods 200 cases of the patients with acute coronary syndrome who treatment with PCI were randomly selected in our hospital during July 2017 to December 2018 as the objects,all of these patients were randomly divided into two groups according to computer-generated number table method,with 100 cases in each group. The patients in control group were given treatment with routine Western medicine,on this basis of the experimental group was given treatment with Xuefu Zhuyu Decoction combined with Xinmailong Injection,the levels of NT-proBNP and THS-TNT,cardiac function,symptom score and platelet function were compared between these two groups. Results After treatment,the level of NT-proBNP was(261.27±71.55)pg/mL,THS-TNT was(8.30±1.61)pg/mL,which were lower than those of the control group(320.20±72.33)pg/mL and(17.29±2.70)pg/mL,respectively,with statistically significant(P<0.05). In the experimental group,the left ventricular end diastolic diameter(LVEDd)and left ventricular end systolic diameter(LVEDs)were all shorter than those of the control group,but the left ventricular ejection fraction(LVEF)of experimental group was higher than that of the control group,with statistically significant(P<0.05). The TCM symptom score of the experimental group was(6.00 ±1.57)points,the blood stasis score was(4.17±1.32) points,which were lower than those of the control group(9.14±1.79)points and(7.80±1.82)points,respectively,with statistically significant(P<0.05). The level of 6-keto-PGF1α of the experimental group was higher than that of the control group,while the level of thromboxane B2(TXB2)was lower than that of the control group,with statistically significant(P<0.05). Conclusion Xuefu Zhuyu Decoction combined with Xinmailong Injection on the patients with acute coronary syndrome after PCI can helpful to improve the the levels of NT-proBNP,THSTNT and cardiac function,as well as reduce the symptom scores,improve platelet function.