口腔微生物与口腔疾病、肠道菌群、肠道疾病的关联性研究进展

Advances in research of correlationship between oral microbes and oral diseases,intestinal flora and intestinal diseases

与微生物感染相关的疾病负担日益引人关注,随着高通量测序等微生物组学技术的不断发展,分析和研究既往难以培养的微生物成为可能,也使得口腔微生物在全身疾病发生发展中的作用逐渐显现。该文探讨了口腔微生物在口腔内外疾病,特别是消化道疾病中的致病机制,并就一些目前研究中关联性较明确的疾病如炎症性肠病、胰腺肿瘤、结直肠肿瘤等进行详细阐述,为进一步研究口腔微生物在全身疾病诊治中的作用提供参考。

The diseases caused by microbial infections arouse growing concerns these days.With progress in microbiome technologies such as high-throughput sequencing technique,it became possible to analyze microbes that were previously hard to cultivate.The role of human oral microbial in the occurrence and development of systemic diseases has gradually become prominent.Here we focus on the human oral microbes and their relationship with oral and extra-oral diseases,especially their involvement in the pathogenesis of digestive diseases.And we elaborate some specific related diseases,such as inflammatory bowel disease,pancreatic tumor and colorectal cancer,which have clear correlations with oral microbes found in previous studies,providing references for their further research in relation to diagnosis and treatment of systemic diseases.