口服布洛芬与对乙酰氨基酚治疗小儿高热的疗效比较

Comparison of oral ibuprofen and acetaminophen in the treatment of children with high fever

目的探讨对小儿高热患者的治疗中服用布洛芬与对乙酰氨基酚的临床效果。方法选取2018年5月~2019年5月本院小儿科收治的高热患儿76例作为研究对象,依据入院接受治疗时间的顺序进行平均分组,甲组(n=38)在常规综合治疗基础上予以口服布洛芬治疗,而乙组(n=38)患儿则口服对乙酰氨基酚治疗,将不同时间点体温水平、不同时间点退热情况、不良反应等作为退热效果的判断标准。结果治疗前、用药后0.5 h两组患儿体温比较,无明显差异(P>0.05);用药后1 h、2 h、4 h甲组体温水平明显低于乙组,差异有统计学意义(P<0.05),甲组治疗总有效率(97.37%)明显高于乙组(84.21%),差异有统计学意义(P<0.05)。结论对于小儿高热患儿,在治疗过程中口服布洛芬与对乙酰氨基酚均有着良好的效果,而布洛芬在退热时间和不良反应方面更具优势,值得临床进一步推广应用。

Objective To investigate the clinical effect of taking ibuprofen and acetaminophen in the treatment of children with high fever.Methods 76 children with high fever admitted to our hospital from May 2018 to May 2019 were selected as the study subjects.The children were averaged according to the order in which they were admitted to the hospital for treatment.Group A(n=38)was given oral ibuprofen,while group B(n=38)was treated with oral acetaminophen.The body temperature at different time points,antipyretic situation at different time points and adverse reactions etc.were chosen the criterion for determining the antipyretic effect.Results There was no significant difference in body temperature between the two groups before treatment and 0.5 h after treatment(P>0.05).The body temperature level of group A was significantly lower than that of group B at 1 h,2 h and 4 h after administration(P<0.05).The total effective rate of group A was 97.37%,which was significantly higher than that of group B(84.21%),and the difference was statistically significant(P<0.05).Conclusion For children with high fever,oral ibuprofen and acetaminophen both have a good effect.But ibuprofen has advantages in antipyretic time and adverse reactions,and is worthy of further clinical promotion and application.