子宫内膜微生物群与不孕症的相关性研究

Study on correlation between endometrial microbiota and infertility

高灵敏度分子生物学技术的出现,为研究子宫内膜微生物群开辟了新的可能,拓展了人们对女性生殖道微生物群的认识。稳定的生态菌群是生殖道健康的关键,菌群比例失衡会导致生殖道感染及增加疾病的发生率,随着生活压力增加、生活方式改变以及环境污染,不孕不育的发病率呈逐渐上升趋势。本文主要对近几年来有关子宫内膜微生物群及其与不孕症和辅助生殖技术结局的相关性研究加以综述,并展望子宫内膜微生物群在生殖医学领域未来的研究方向。

The emergence of high-sensitivity molecular techniques has opened up new possibilities to explore the endometrial microbiota and expanded people’s views on the female reproductive tract microbiota.Stable ecological flora is the key to reproductive tract health,and imbalance of microbial population ratio can cause reproductive tract infection and increase the incidence of diseases.With the increase of life pressure,lifestyle change and environmental pollution,the incidence of infertility is gradually increasing.This paper mainly reviews the recent studies on the endometrial microbiota and its correlation with infertility in recent years,and looks forward to the future research direction of endometrial microbiota in the field of reproductive medicine.