负压创面联合富血小板血浆对慢性难愈性创面患者疼痛及炎症指标的影响

Effects of Negative Pressure Wound Therapy Combined with Platelet-Rich Plasma on Pain Degree and Inflammatory Index in Patients with Chronic Refractory Wounds

目的:探讨负压创面治疗技术联合富血小板血浆对修复慢性难愈性创面患者疼痛程度及炎症指标的影响。方法:选取2017年6月-2019年1月我院收治的60例慢性难愈性创面患者为研究对象,按分层随机法分为观察组和对照组,各30例。对照组仅以负压创面治疗,观察组在其基础上联合富血小板血浆治疗,对比两组创面修复效果及患者疼痛程度及炎症指标变化。结果:观察组住院时间、创面愈合时间以及二期手术准备时间均短于对照组(P<0.05);治疗前两组WBC、CRP和ESR水平对比差异无统计学意义(P>0.05),治疗后两组WBC、CRP和ESR水平明显低于治疗前,且观察组治疗后WBC、CRP和ESR水平低于对照组治疗后(P<0.05);两组治疗前VAS评分比较无显著差异(P>0.05),治疗后3天和7天两组VAS评分均低于治疗前(P<0.05),观察组治疗后3天和7天VAS评分低于对照组(P<0.05)。结论:在慢性难愈性创面中联合应用负压创面治疗技术和富血小板血浆可以促进患者创面愈合,缩短住院时间,改善炎症反应,减轻疼痛,有一定借鉴意义。

Objective:To investigate the effects of negative pressure wound therapy combined with platelet-rich plasma on pain degree and inflammatory index in patients with chronic refractory wounds.Methods:A total of 60 patients with chronic refractory wounds admitted to our hospital from June 2017 to January 2019 were selected as the research objects and randomly divided into observation group and control group(30 cases each).The control group was treated with only negative pressure wound therapy,and the observation group was treated with platelet-rich plasma on the basis of it.Results:The length of hospital stay,wound healing time and second stage operation preparation time in the observation group were shorter than those in the control group(P<0.05).There was no statistically significant difference in the levels of WBC,CRP and ESR between the two groups before treatment(P>0.05).The levels of WBC,CRP and ESR in the two groups after treatment were significantly lower than those before treatment,and the levels of WBC,CRP and ESR in the observation group after treatment were lower than those in the control group after treatment(P<0.05).There was no significant difference in VAS scores between the two groups before treatment(P>0.05).VAS scores of the two groups on day 3 and 7 after treatment were lower than those before treatment(P<0.05),and those of the observation group on day 3 and 7 after treatment were lower than those of the control group(P<0.05).Conclusion:The combination of supportive negative pressure and platelet-rich plasma in chronic refractory wounds can promote wound healing,shorten hospital stay,improve inflammatory response and relieve pain.