Wnt10b基因的生理功能及其在绒毛周期性生长中的作用研究进展

Research Advances on Physiological Function of Wnt10b Gene and Its Role in Periodic Growth of Cashmere

绒山羊的绒毛生长具有周期性的特点,受多种因素的影响。Wnt10b基因作为Wnt家族的重要成员之一,在动物体脂肪的生成、骨骼的生成和某些疾病(如肿瘤)的产生、毛囊的生成,以及毛发基板的生长与保持活性状态等方面发挥着重要作用。对Wnt10b的来源、结构、生理功能、调控机制及其对毛囊周期性生长的影响进行综述,以期为Wnt10b促进绒毛周期性生长的作用机理研究提供参考。

The cashmere growth of cashmere goat has the characteristic of periodicity and is affected by many factors.Wnt10b gene,as one of the important members of Wnt family,plays an important role in the formation of fat and bone,occurrence of some diseases(such as tumor),generation of hair follicle,and the growth and active state maintenance of hair plate in animal.In this paper,the origin,structure,physiological function,regulatory mechanism of Wnt10b and its influence on the growth cycle of hair follicle are reviewed,in hoping to provide reference for understanding the mechanism of Wnt10b in promoting the periodic growth of cashmere.