复方α-酮酸用于终末期肾病维持性血液透析患者中对其微炎症状态、营养状态的影响

Effects of compoundα-keto acid on micro-inflammatory status and nutritional status in patients with maintenance hemodialysis of end-stage renal disease

目的 探讨复方α-酮酸用于终末期肾病维持性血液透析患者中对其微炎症状态、营养状态的影响.方法 选取2016年9月至2019年9月收治的行维持性血液透析治疗的终末期肾病患者72例,以随机数字表法将其分为对照组和观察组,各36例.对照组仅采用维持性血液透析治疗,观察组则在维持性血液透析治疗基础上联合复方α-酮酸治疗.比较两组患者治疗前、后微炎症指标和营养指标水平.结果 治疗后,观察组的hs-CRP、IL-6及TNF-α水平均低于治疗前和对照组,差异具有统计学意义(P<0.05).治疗后,观察组的ALB、Hb及TRF水平均高于治疗前和对照组,差异具有统计学意义(P<0.05).结论 在终末期肾病患者维持性血液透析中应用复方α-酮酸可减轻微炎症反应,提高营养状况,值得临床推广应用.

Objective To investigate the effects of compoundα-keto acid on micro-inflammatory status and nutritional status in patients with maintenance hemodialysis of end-stage renal disease.Methods A total of 72 patients with end-stage renal disease treated with maintenance hemodialysis admitted from September 2016 to September 2019 were selected and divided into control group and observation group according to random number table method,with 36 cases in each group.The control group was only treated with maintenance hemodialysis,while the observation group was treated with compoundα-keto acid on the basis of maintenance hemodialysis.The levels of microinflammatory indexes and nutritional indexes were compared between the two groups before and after treatment.Results After treatment,the levels of hs-CRP,IL-6 and TNF-αin the observation group were lower than those before treatment and in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of ALB,Hb and TRF in the observation group were higher than those before treatment and in the control group,and the differences were statistically significant(P<0.05).Conclusion The application of compoundα-keto acid in maintenance hemodialysis of patients with end-stage renal disease can reduce microinflammation response and improve nutritional status,which is worthy of clinical promotion and application.