腹腔镜手术与传统开腹手术对胆总管囊肿患儿应激反应及炎性因子水平的影响

Effects of laparoscopic surgery and traditional open surgery on the levels of stress response and inflammatory factors in children with choledochal cyst

目的分析腹腔镜手术与传统开腹手术对胆总管囊肿患儿应激反应及炎性因子水平的影响.方法 将126例胆总管囊肿患儿按手术方式分为观察组(腹腔镜手术)和对照组(开腹手术),各63例.比较两组的治疗情况.结果 术后3 d,观察组的COR、MDA、SOD、CRP、IL-6、IL-8水平均低于对照组(P<0.05).术后7 d,两组的GPT、GOT、TBL、DBL水平均降低,且观察组低于对照组(P<0.05).观察组的手术时间长于对照组,术中出血量、首次排气时间、住院时间均优于对照组(P<0.05).结论 腹腔镜手术较开腹手术能有效降低胆总管囊肿患儿应激指标和炎性因子水平,改善肝功能指标,减少术中出血量,缩短住院时间,值得临床推广和应用.

Objective To analyze the effects of laparoscopic surgery and traditional open surgery on the levels of stress response and inflammatory factors in children with choledochal cyst.Methods A total of 126 children with choledochal cyst were divided into observation group(laparoscopic surgery)and control group(open surgery)according to surgical methods,with 63 cases in each group.The treatment condition of the two groups were compared.Results At 3 days after surgery,the levels of COR,MDA,SOD,CRP,IL-6 and IL-8 in the observation group were lower than those in the control group(P<0.05).At 7 days after surgery,the GPT,GOT,TBL,and DBL levels of the two groups decreased,and those in the observation group were lower than the control group(P<0.05).The operation time of the observation group was longer than that of the control group,and the intraoperative blood loss volume,the time of first exhaustion and the length of hospitalization were better than those of the control group(P<0.05).Conclusion Compared with open surgery,laparoscopic surgery can effectively reduce the stress index and inflammatory factor levels of children with choledochal cyst,improve the liver function index,and it can reduce the intraoperative blood loss volume and shorten length of hospitalization,which is worthy of clinical promotion and application.