长链非编码RNA在妇科肿瘤中的研究进展

Advances in Research of Long Non-Coding RNA in Gynecological Tumors

长链非编码RNA(long non-coding RNA,lncRNA)是一类长度超过200个核苷酸的RNA片段,由于没有开放阅读框,不能编码蛋白质,曾经被认为是基因转录过程中的“噪音”被学者所忽视。近年,由于表观遗传学技术揭示了lncRNA在人类疾病发病机制中的重要作用,使其成为研究的热点。目前已有研究证实,部分lncRNA分子的表达水平与人类多种肿瘤的发生、发展和耐药有关,lncRNA有望成为新型肿瘤标志物和治疗靶点,为肿瘤治疗探索新途径。综述近年lncRNA在妇科肿瘤中的研究成果,为研究lncRNA与肿瘤的关系、开发肿瘤靶向治疗奠定基础。

Long non-coding RNA(lncRNA)is a kind of RNA molecule with a length of more than 200 nucleotides.Because there is no open reading frame,it can′t encode protein.It was thought to be the"noise"in the process of gene transcription and was ignored by scholars.With the progress of epigenetics technology in recent years,lncRNA is found to play an important role in the pathogenesis of human disease.Because of its great value,it has become a hot research topic of many scholars.It has been confirmed that lncRNA molecule expression level is related to the occurrence and development,drug resistance in a variety of human tumor disease.It is expected to become a promising new tumor marker and therapeutic target in the future,and explore new therapeutic approaches for tumor treatment.In recent years,the research results of lncRNA in gynecological tumors have been reviewed,so as to provide help for the future research on the relationship between lncRNA and tumors and lay a foundation for the better development of targeted therapy for tumors.