环状RNA的研究进展及胰腺癌中的应用

Current progress of circular RNA and the application in pancreatic cancer

胰腺癌起病隐匿、进展迅速、预后极差,在我国发病人群有年轻化的趋势。早期诊断和精准治疗能有效地改善胰腺癌患者的预后,延长患者的生存期。因此,探索新的诊断方法和开发新的药物靶点依然是胰腺癌研究的关键点。环状RNA(circRNA)作为一类重要的非编码RNA分子,在多种恶性肿瘤中被证实与肿瘤的发生、发展、预后相关。由于其结构稳定、分布广泛、组织特异等特点,circRNA作为分子诊断标志物和药物靶点比其他非编码RNA更有优势。由于circRNA与外泌体的密切联系,近年来外泌体相关研究能进一步推动circRNA在肿瘤领域的临床转化。本文就circRNA近年来的研究进展作一综述,并着重阐述其在胰腺癌领域的研究现状和应用前景。

With insidious onset and dismal prognosis,mortality of pancreatic cancer is very high,and incidence in younger patients of China is increasing.Early detection and specific treatment are able to modify the prognosis and prolong the survival of patients.So exploration of new diagnostic method and development of novel therapy target are still the key points in research of pancreatic cancer.As an important part of non-coding RNA,circular RNA(circRNA)has been proven to be involved in the genesis,progress and prognosis.When concerned as diagnostic marker and pharmaceutic target,circRNA has more advantages than others for its stable structure,extensive distribution and specificity of tissue.Because of the connection with exosomes,the researches of exosome make a big effort on translation of circRNA in the clinical management of malignant tumors.This paper will review the latest progress of circRNA and focus on the current research and possible future application of circRNA in pancreatic cancer.