肿瘤相关巨噬细胞促进胰腺癌进展的机制

Mechanism of tumor-associated macrophages promoting the progression of pancreatic cancer

胰腺癌恶性程度高,大部分对化疗及放疗不敏感,肿瘤进展快,患者预后差。研究导致胰腺癌进展的机制具有重要的意义。肿瘤相关巨噬细胞(TAMs)是肿瘤微环境中最重要的细胞成分之一,巨噬细胞通过响应肿瘤微环境中各种细胞因子、信号通路的作用极化为表达M2表型的TAMs,并通过辅助免疫逃逸、促使肿瘤周围纤维化、调控血管生成、促进细胞增殖等多种机制调节胰腺癌的进展。本文将对近年来TAMs促进胰腺导管腺癌进展的机制作一综述。

Pancreatic cancer is a highly lethal disease due to rapid progression and poor response to chemotherapy and radiotherapy,and prognosis of patients with pancreatic cancer remains grim.Advances in tumor microenvironment researches uncovered the pivotal role of tumor associated macrophages(TAMs)in tumor microenvironment.Macrophages are polarized into TAMs expressing the M2 phenotype in response to the action of various cytokines and signaling pathways in the tumor microenvironment.TAMs could regulate the development of pancreatic cancer through multiple mechanisms,including promoting immune escape,fibrosis,angiogenesis,cell proliferation and cell invasion.In this study,we reviewed the mechanisms by which TAMs promote the progression of pancreatic ductal adenocarcinoma.