类器官在胰腺癌研究中的应用和展望

Application and perspectives of organoids in pancreatic cancer research

多年以来,研究者对人类胰腺癌的研究,多建立在传统的二维代谢模型或基因工程小鼠(GEMMs)等传统模型之上。但是,这些模型并不能精确地反映胰腺癌的特性以及胰腺癌微环境的状态。然而,类器官(Organoid)作为一种新颖的体外三维培养技术,已在胰腺癌、肝癌、胃肠道肿瘤、结肠腺癌以及Barrett食管等诸多疾病的科学研究中建立了可靠的体外肿瘤模型。其中,胰腺癌类器官模型的稳定建立,为研究胰腺癌的生物学特性、探索更具特异性的抗胰腺癌药物以及制定胰腺癌症的个性化治疗方案开辟了新的研究方向。本文就类器官技术在胰腺癌相关研究中的应用做出了分析并进行展望。

For many years,the research on human pancreatic cancer has been based on the traditional two-dimensional metabolism model or genetic engineering mouse model.But these models can not accurately reflect the characteristics of pancreatic cancer and the status of pancreatic cancer microenvironment.As a novel three-dimensional culture technique in vitro,organoid has established reliable in vitro tumor models for pancreatic cancer,liver cancer,gastrointestinal cancer,colon adenocarcinoma,Barrett esophagus and many other diseases.It opens up a new horizon for studying the biological characteristics of pancreatic cancer,exploring more specific anti-pancreatic drugs and formulating individualized treatment schemes for pancreatic cancer.In this paper,the application of organoid technology in pancreatic cancer related research is analyzed and prospected.