99例伴6号染色体异常的血液病分析

Analysis of 99 patients with hematopathies and aberrations of chromosome 6

目的探讨6号染色体异常在血液病中的发生及其预后意义。方法回顾分析99例伴6号染色体异常的血液病患者的一般临床资料和核型分析结果。结果99例患者主要为急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)、淋巴瘤、多发性骨髓瘤、骨髓增生异常及慢性淋巴细胞白血病等,其中ALL占比最大,将ALL患者患者分为+6/-6、6p异常和6q异常3组,3组ALL患者的性别、血红蛋白、血小板计数差异无统计学意义(P>0.05)。而伴6q异常的ALL患者年龄和白细胞计数均明显高于+6/-6组,差异有统计学意义(P<0.05);多因素COX分析显示6p/6q异常及年龄大于14岁是影响ALL患者预后的危险因素。ALL各组1年总生存率分别90.9%、20.0%、55.6%,6q和6p组1年总生存率均低于+6/-6组(P<0.05)。结论伴6号染色体异常常见于B细胞性疾病,ALL中伴6q/6p异常的患者预后较差,探讨6号染色体异常对患者预后具有一定的意义。

Objective To explore the significance of chromosome 6 aberrations for the occurrence and prognosis of hematopathies.Methods Clinical data and the cytogenetic results of 99 patients with hematopathies and aberrations of chromosome 6 were analyzed.Results The patients mainly had acute lymphoblastic leukemia(ALL),lymphoma,multiple myeloma,and myelodysplastic syndrome.ALL was the most common among the selected disorders.Based on their main abnormalities,ALL patients were divided into+6/-6,6p and 6q groups.No significant difference was found in the gender,hemoglobin and platelet count between the three groups(P>0.05).The age and white cell count in those with 6q aberrations were significantly higher compared with the+6/-6 group(P<0.05).Multivariate COX analysis suggested that the 6p/6q aberrations and age are risk factors for the prognosis.The 1-year overall survival rate of the 6p and 6q groups were lower than that of the+6/-6 group(P<0.05).Conclusion Aberrations of chromosome 6 are common in B-cell disease,and patients with ALL and 6q aberration have a poorer prognosis.Analysis of chromosome 6 aberration has a significance for the prognosis.