不同剂量黄体酮联合低分子肝素钠治疗先兆流产临床疗效的比较研究

A comparative study on the clinical effect of progesterone combined with low molecular weight heparin for threatened abortion

目的比较不同剂量黄体酮联合低分子肝素钠治疗先兆流产的临床疗效。方法选取贵港市中西医结合骨科医院2015年8月—2018年12月收治的先兆流产孕妇88例,随机分为对照组和观察组,各44例。对照组采用常规剂量黄体酮治疗,观察组采用低剂量黄体酮联合低分子肝素钠治疗。比较两组临床疗效、腹痛缓解时间、腰酸缓解时间、止血缓解时间、人绒毛膜促性腺激素(HCG)恢复时间、保胎成功率、新生儿畸形率、新生儿体质量和分娩妊娠时间。结果观察组总有效率高于对照组,腹痛缓解时间、腰酸缓解时间、止血缓解时间和HCG恢复时间短于对照组,保胎成功率、新生儿体质量高于对照组,分娩妊娠时间长于对照组(P<0.05)。两组新生儿畸形率比较,差异无统计学意义(P>0.05)。结论与常规剂量黄体酮相比,低剂量黄体酮联合低分子肝素钠治疗先兆流产的临床疗效较优,可改善孕妇临床症状,改善新生儿情况。

Objective To compare the clinical effect of progesterone combined with low molecular weight heparin sodium for threatened abortion.Methods A total of 88 cases of pregnant women with threatened abortion were selected from August 2015 to December 2018 in Integrated Traditional Chinese and Western Medicine Orthopedic Hospital of Guigang,which were randomly divided into control group and research group,44 cases each of group.The control group was treated with conventional dose of progesterone,and the observation group was treated with low dose of progesterone combined with low molecular weight heparin sodium.The clinical effect,abdominal pain relief time,lumbar acid relief time,hemostasis relief time,HCG recovery time,success rate of fetal protection,neonatal deformity rate,neonatal body mass and delivery pregnancy time were compared between the two groups.Results The total effective rate of the observation group was higher than the control group,abdominal pain relief time,lumbar acid relief time,hemostasis relief time and HCG recovery time were shorter than the control group,the success rate of fetal protection,neonatal body mass were higher than the control group,and delivery pregnancy time was longer than the control group(P<0.05).There was no significant difference in neonatal deformity rate between the two groups(P>0.05).Conclusion Compared with the conventional dose of progesterone,the low dose of progesterone combined with low molecular weight heparin sodium has a better clinical effect for threatened abortion,which can improve the clinical symptoms of pregnant women and the situation of newborns.