先兆流产与新生儿黄疸的相关性研究

Study on the correlation between threatened abortion and neonatal jaundice

目的探讨先兆流产与新生儿黄疸的相关性。方法回顾性分析2018年8月至2019年5月在湖州市妇幼保健院接受治疗的140例黄疸新生儿资料。按其孕母在孕期是否出现过先兆流产症状将研究对象分为观察组和对照组,每组各70例。对比两组黄疸新生儿的血清总胆红素(TBiL)、C反应蛋白(CRP)、转铁蛋白(TRF),通过Spearman相关分析对先兆流产与黄疸新生儿血清TBiL、CRP、TRF的相关性进行检测。结果观察组的血清TBiL、CRP表达水平明显高于对照组,血清TRF表达水平明显低于对照组(t值分别为46.110、53.910、12.520,均P<0.001);先兆流产与黄疸新生儿的血清TBiL、CRP呈正相关,与血清TRF呈负相关(r值分别为0.576、0.643、-0.656,均P<0.001)。结论先兆流产与新生儿黄疸的发生存在相关性。纠正先兆流产新生儿的血清TBiL、CRP、TRF表达水平,可降低新生儿时期的黄疸发生率。

Objective To explore the correlation between threatened abortion and neonatal jaundice.Methods A retrospective analysis was made on 140 cases of jaundiced newborns treated in our hospital from August 2018 to May 2019.The study subjects were divided into observation group and control group according to whether their pregnant women had symptoms of threatened abortion during pregnancy,with 70 cases in each group.The serum total bilirubin(TBiL),C-reactive protein(CRP) and transferrin(TRF) were compared between the two groups.The correlations between threatened abortion and serum TBiL,CRP and TRF ware analyzed by Spearman correlation analysis.Results The levels of serum TBIL and CRP in the observation group were significantly higher than those in the control group,and the level of serum TRF was significantly lower than that in the control group(t=46.11,53.91,12.52,P<0.001);There was a positive correlation between threatened abortion and serum TBIL,CRP,and a negative correlation with serum TRF(r=0.576,0.643,-0.656,P<0.001).Conclusion There was a correlation between threatened abortion and jaundice in neonates.Correcting the expression levels of TBIL,CRP and TRF in the serum of neonates with threatened abortion can reduce the incidence of jaundice in neonatal period.