类风湿关节炎患者外周血CD64与疾病活动度炎症介质水平的相关性

Relationship between peripheral blood CD64 level and disease activity,inflammatory mediators levels in patients with rheumatoid arthritis

目的探讨类风湿关节炎患者外周血簇分化抗原64水平与疾病活动度、炎症介质水平的相关性.方法将67例类风湿关节炎患者设为观察组,65名健康体检者设为对照组.检测两组被试外周血簇分化抗原64、C-反应蛋白、类风湿因子、抗环瓜氨酸肽水平及红细胞沉降率,采用Spearman相关性分析探讨簇分化抗原64与各指标间的关系.结果治疗前观察组外周血类风湿因子、C-反应蛋白、红细胞沉降率、抗环瓜氨酸肽及簇分化抗原64水平均显著高于对照组(P<0.05);治疗后观察组外周血类风湿因子、抗环瓜氨酸肽、簇分化抗原64、红细胞沉降率及C-反应蛋白水平均较治疗前显著降低(P<0.05),但类风湿因子、抗环瓜氨酸肽、红细胞沉降率及簇分化抗原64与对照组比较差异仍有统计学意义(P<0.05).治疗后观察组关节肿胀数、关节压痛数较治疗前显著减少(P<0.05),关节疼痛度及类风湿关节炎患者病情评价评分均较治疗前显著降低(P<0.05).类风湿关节炎患者外周血簇分化抗原64水平与类风湿关节炎患者病情评价评分、C-反应蛋白、红细胞沉降率水平呈显著正相关(P<0.05),与类风湿因子、抗环瓜氨酸肽无明显相关性(P>0.05).结论类风湿关节炎患者外周血簇分化抗原64水平与疾病活动度、红细胞沉降率、C-反应蛋白水平密切相关,可作为该病临床诊治的重要生物学指标.

Objective To explore the relationship between the peripheral blood CD64 level and the disease activity and inflammatory mediators levels in patients with rheumatoid arthritis.Methods 67 patients with rheumatoid arthritis were selected as observation group.65 cases of patients who underwent health examination were selected as control group.Peripheral blood RF,CCP,CD64 level,expression levels of Creactive protein(CRP),rheumatoid factor(RF)and anti-cyclic citrullinated peptide(CCP)and erythrocyte sedimentation rate(ESR)were measured in each patient.Spearman correlation analysis was used to explore the relationship between CD64 and various indicators.Results The levels of peripheral blood RF,CRP,ESR,CCP and CD64 of patients with rheumatoid arthritis in the observation group before treatment were significantly higher than those in the control group(P<0.05).After treatment,the peripheral blood RF,CCP,CD64,erythrocyte sedimentation rate,and C-reactive protein levels in the observation group were significantly reduced than those before treatment(P<0.05),and the differences were statistically significant compared with the control group(P<0.05).The number of joint swelling,joint tenderness,joint pain and the disease evaluation scores in the observation group after treatment were significantly lower than those before treatment(P<0.05).The levels of peripheral blood CD64 in peripheral blood of patients with rheumatoid arthritis were significantly positively correlated with the disease evaluation scores,C-reactive protein,and red blood cell sedimentation rate(P<0.05).There was no significant correlation with rheumatoid factor and CCP(P>0.05).Conclusions Peripheral blood CD64 level of patients with indicator for the diagnosis and treatment of rheumatoid arthritis.