锌指蛋白与消化系统肿瘤

Zinc finger proteins and digestive system cancers

锌指蛋白是人类基因组中最大的转录家族,通过促癌或抑癌作用广泛参与消化系统肿瘤的发生发展过程。研究表明多种锌指蛋白的表达异常与胃癌、肝癌、结直肠癌和胰腺癌患者的临床病理特征及预后密切相关。研究锌指蛋白的作用机制有助于为临床治疗消化系统肿瘤提供新的靶点。

Zinc finger proteins(ZNFs)belong to the largest transcriptional factor family in human genome.ZNFs are widely involved in the development and progression of digestive system cancers by promoting or inhibiting carcinogenesis.Studies have shown that the abnormal expressions of various ZNFs are closely related to the clinicopathologic features and prognosis of patients with digestive system cancers,including gastric cancer,liver cancer,colorectal cancer and pancreatic cancer.Exploring the underlying mechanism of ZNFs will help to provide new targets for clinical treatment of digestive system cancers.