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二甲双胍联合西格列汀治疗2型糖尿病的临床效果观察 被引量:5

Clinical effect of metformin combined with sitagliptin in the treatment of type 2 diabetes
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摘要 目的观察二甲双胍联合西格列汀治疗2型糖尿病的临床效果。方法选取2018年1月-2019年4月漳州市人民医院收治的2型糖尿病患者80例为研究对象,采取随机数字表法分为对照组和观察组,每组40例。对照组给予二甲双胍治疗,观察组给予二甲双胍联合西格列汀治疗,比较2组治疗前后血糖控制效果及不良反应。结果治疗12周后,2组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于治疗前,且观察组低于对照组(P<0.01);2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论2型糖尿病患者采用二甲双胍联合西格列汀治疗效果较好,可提高血糖控制效果,不良反应少,值得临床推广应用。 Objective Observe the clinical effect of metformin combined with sitagliptin in the treatment of type 2 diabetes.Methods 80 patients with type 2 diabetes admitted to People’s Hospital of Zhangzhou City from January 2018 to April 2019 were selected as the research object,and random number table method was used to divide them into a control group and an observation group,with 40 cases in each group.The control group was given metformin,and the observation group was given metformin combined with sitagliptin.Compare the blood glucose control effect and adverse reactions before and after treatment in the two groups.Results After 12 weeks of treatment,the fasting blood glucose,blood glucose at 2 hours after meal,and glycated hemoglobin levels in the two groups were lower than before treatment,and the observation group was lower than the control group(P<0.01).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment effect of metformin combined with sitagliptin in patients with type 2 diabetes is better,it can improve the blood glucose control effect,and has fewer and mild adverse reactions,so it is worthy of clinical promotion and application.
作者 陈晋 CHEN Jin(Department of Pharmacy,People's Hospital of Zhangzhou City,Fujian Province,Zhangzhou 363000,China)
出处 《临床合理用药杂志》 2020年第14期7-8,共2页 Chinese Journal of Clinical Rational Drug Use
关键词 2型糖尿病 二甲双胍 西格列汀 临床效果 Type 2 diabetes Metformin Sitagliptin Clinical effect
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