骨密度T值与老年冠心病的相关性

Correlation between bone density T value and coronary heart disease in the elderly

目的探讨骨密度T值与老年冠心病的相关性。方法回顾性分析于某院行冠状动脉造影检查并完善骨密度检查的512例老年患者的临床资料,根据冠状动脉造影结果分为冠心病组(273例)和非冠心病组(239例)。根据双能X线骨密度检查结果分为低骨密度组(302例)和骨密度正常组(210例)。分析比较各组患者的一般情况、实验室检查指标、骨密度T值的差异,应用Logistic回归分析法分析老年冠心病发病的危险因素。结果512例老年患者中,与非冠心病组相比,冠心病组年龄较大、糖尿病的比例较高,骨密度T值较低(P<0.05或<0.01)。与骨密度正常组相比,低骨密度组年龄较大、女性、糖尿病的比例较高,骨密度T值较低,UA较高(P<0.05或<0.01)。相关性分析显示,骨密度T值与年龄、碱性磷酸酶、空腹血糖(P<0.01)均呈负相关;骨密度T值与UA(P<0.001)呈正相关。回归分析结果显示,年龄大、糖尿病为低骨密度发生的危险因素。单因素、多因素Logistic回归分析结果均显示,骨密度T值高(P<0.05)仍是冠心病的独立危险因素。结论低骨密度T值是老年冠心病发病的独立危险因素。

Objective To investigate the correlation between bone mineral density T value and coronary heart disease in the elderly.Methods Retrospective analysis was performed on 512 elderly patients who underwent coronary angiography and bone mineral density examination.According to the results of coronary angiography,273 patients in the coronary heart disease group and 239 patients in the non-coronary heart disease group.According to the results of DXA bone mineral density examination,there were 302 cases of low bone density group and 210 cases of normal bone density group.The general conditions of each group of patients,the difference of laboratory test indicators,and bone density T value were compared.Logistic regression analysis was used to analyze the risk factors of coronary heart disease in the elderly.Results In 512 elderly patients,the T-value of bone density was lower in the coronary heart disease group and the risk of low bone mineral density was higher in the non-coronary heart disease group(P<0.05 or<0.01).Compared with the normal bone density group,the group with low bone mineral density had the high proportion of older,female and diabetic patients,the T-value of bone mineral density was lower,and uric acid was higher(P<0.05 or<0.01).Correlation analysis showed that the bone density T value was negatively correlated with age,ALP,FBG(P<0.01),the bone density T value was positively correlated with uric acid(P<0.001).Regression analysis showed that aging,diabetes,were risk factors for low bone density.The results of single factor and multivariate logistic regression analysis showed that high bone density T value was an independent risk factor for coronary heart disease(P<0.05).Conclusion Low bone density T value is an independent risk factor for the onset of coronary heart disease in the elderly.