linc00673在结直肠癌患者血浆中的表达及临床意义

The expression and correlation analysis of linc00673 in plasma of patients with colorectal cancer between clinical features

目的检测结肠息肉和结直肠癌患者血浆中linc00673的表达水平,为血浆linc00673在结直肠癌早期筛查中的应用提供理论依据。方法收集某院2018年6月至2018年12月期间收治的结肠息肉、结直肠癌住院患者,共108例作为研究对象。采用real-time PCR检测linc00673在结直肠癌和结肠息肉患者血浆中的表达水平,分析linc00673表达水平与结直肠癌患者年龄、性别、TNM分期、肿瘤部位、大体类型、淋巴结转移及肿瘤大小的临床相关性。结果结直肠癌患者血浆中linc00673表达水平明显高于结肠息肉患者(P<0.05);其表达水平与患者年龄、性别、TNM分期、肿瘤部位、大体形态和淋巴结转移无关,仅与肿瘤体积大小呈正相关(P<0.01)。结论血浆linc00673水平与结直肠癌发生、发展密切相关,可作为结直肠癌早期筛查的潜在标志物。

Objective To detect the expression of linc00673 in patients with colorectal cancer,and then explore the relationship between the expression of plasma linc00673 and clinical symptoms.Methods Totally108 hospitalized patients with colon polyps and colorectal cancer admitted to Shenzhen People′s Hospital were enrolled.Real-time PCR was used to detect the difference in the expression of linc00673 in plasma of colorectal cancer and rectal polyps.The correlation between linc00673 and patient age,gender,TNM tumor stage,tumor location,gross type and lymph node metastasis and tumor volume was analyzed.Results Linc00673 was highly expressed in colorectal cancer tissues(P<0.05).Correlation analysis showed that high expression of linc00673 was not associated with age,gender,TNM tumor stage,tumor location,gross type and lymph node metastasis,and was positively correlated with tumor volume(P<0.01).Conclusion The high expression of linc00673 in colorectal cancer tissues suggests that linc00673 may be a potential marker for the diagnosis of colorectal cancer,which may provide a theoretical basis for the diagnosis and targeted therapy of colorectal cancer.