细菌中2-甲基柠檬酸循环研究进展

Research progress in 2-methylcitrate cycle in bacteria

2-甲基柠檬酸循环广泛分布于细菌中,参与丙酸或丙酰-CoA的分解代谢。我们一直致力于微生物代谢调控方面的研究,并以苏云金芽胞杆菌为研究对象在2-甲基柠檬酸循环的代谢调控及生理功能方面取得了新的进展。本文将从2-甲基柠檬酸循环关键酶基因的组成、关键酶基因的转录调控和该循环参与的生理功能3个方面介绍细菌中2-甲基柠檬酸循环的研究进展。同时,对该循环研究中存在的相关科学问题和未来的研究重点作简要评述,并对该循环关键酶作为药物靶标在病源菌感染防治方面的应用进行展望。

The 2-methylcitrate cycle is a widely distributed carbon metabolic pathway playing a crucial role in consuming propionate or propionyl-CoA in bacteria.We have been working on the field of microbial metabolic regulation,and made new progress in the transcriptional mechanism and physiological function of 2-methylcitrate cycle in Bacillus thuringiensis.In this paper,current researches on the composition and transcription regulation of the key genes in 2-methylcitrate cycle,and the physiological functions of 2-methylcitrate cycle are reviewed.Meanwhile,the existing scientific problems and future research topics about this cycle are discussed.In addition,the potential application of the key enzymes in 2-methylcitrate cycle as drug targets for prevention and treatment of bacterial infection is also proposed.