葡萄糖酸锌联合西咪替丁结合基础治疗对疱疹性咽峡炎患儿心肌酶与C-反应蛋白的影响

Effect of combined treatment with zinc gluconate and cimetidine on myocardial enzyme and C-reactive protein in children with herpetic angina

目的研究葡萄糖酸锌联合西咪替丁结合基础治疗对疱疹性咽峡炎患儿心肌酶与C-反应蛋白(CRP)的影响。方法随机选取2017年6月-2019年6月于该院进行治疗的疱疹性咽峡炎患儿共86例,按照数字随机表法分为观察组和对照组,各43例。对照组使用常规治疗方法,观察组在对照组的基础上使用葡萄糖联合西咪替丁治疗。分别对两组患儿的疗效、临床症状消退时间、心肌酶水平和CRP水平进行检测与统计分析。结果观察组治疗有效率(95. 35%)显著高于对照组(81. 40%)(χ^2=4. 070,P=0. 044);观察组体温下降时间(2. 35±0. 37) d、胃纳恢复时间(3. 04±0. 42) d和口腔疱疹消退时间(3. 28±0. 47) d均明显短于对照组(4. 37±0. 63、5. 87±0. 7、5. 99±0. 71) d,差异均有统计学意义(t=18. 130,P=0. 000;t=3. 153,P=0. 003;t=20. 871,P=0. 000);治疗后两组患儿乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)和CRP水平均明显下降,并且观察组四项指标(131. 43±23. 54) U/L、(103. 34±19. 38) U/L、(16. 03±5. 83) U/L、(1. 50±0. 63) mg/L均明显低于对照组[(168. 57±22. 93) U/L、(121. 35±21. 8) U/L、(24. 84±7. 21) U/L、(3. 49±0. 72) mg/L],差异均有统计学意义(t=7. 411,P=0. 000;t=6. 294,P=0. 000;t=6. 725,P=0. 000;t=8. 836,P=0. 000)。结论葡萄糖酸锌联合西咪替丁结合基础治疗对疱疹性咽峡炎患儿心肌酶水平和CRP控制作用更好,治疗效果更优,值得临床推广。

Objective To study the effects of zinc gluconate combined with cimetidine combined with basal therapy on myocardial enzymes and C-reactive protein in children with herpetic angina.Methods Randomly selected from June 2017~June 2019 in our hospital for treatment of herpes angina in children with a total of 86 cases,according to the number of random table method into the observation group and the control group of 43 cases,the control group using conventional treatment,The observation group in the control group based on the use of glucose combined with cimetidine treatment.The levels of Caspase and C-reactive protein in the patients were measured and analyzed statistically.Results The effective rate of the treatment group(95.35%)was significantly higher than that of the control group(81.40%)(χ2=4.070,P=0.044).The time of body temperature decrease(2.35±0.37 h),the recovery time of stomach(3.04±0.42 h)and the time of disappearance of oral herpes(3.28±0.47 h)were shorter in the observation group than in the control group(4.37±0.63 h,5.87±0.7 h,5.99±0.71 h)(t=18.130,P=0.000;t=3.153,P=0.003;t=20.871,P=0.000).After treatment,the levels of LDH,CK,CK-MB and CRP in the two groups were significantly decreased,and the four indexes in the observation group(131.43±23.54 U/L,103.34±19.38 U/,16.03±5.83 U/L,1.50±0.63 mg/L)were significantly lower than those in the control group(168.57±22.93 U/L,121.35±21.8 U/L,24.84±7.21 U/L,3.49±0.72 mg/L)(t=7.411,P=0.000;t=6.294,P=0.000;t=6.725,P=0.000;t=8.836,P=0.000).Conclusion Zinc gluconate combined with cimetidine combined with basal therapy on herpes angina in children with myocardial enzyme levels and C-reactive protein has a better control role,and has a better therapeutic effect,which is worthy of clinical promotion.