碱性成纤维生长因子对皮肤损伤修复作用的研究进展

Progress in research on fibroblast growth factor 2 in repair of skin injury

皮肤损伤是临床常见疾病之一,大多由撕裂、割伤或挫伤等急性创伤导致。在皮肤损伤修复过程中,多种细胞通过分泌细胞因子参与创面愈合,如碱性成纤维生长因子(fibroblast growth factor 2,FGF2或bFGF)、血小板源性生长因子(platelet-derived growth factor,PDGF)和转化生长因子β(transforming growth factor-β,TGF-β)等,其中FGF2可通过促进血管生成、肉芽形成,减少瘢痕形成,加速上皮化促进伤口愈合。FGF2半衰期短,在体内易受酶和皮肤微环境的影响,在伤口处保留时间短暂,降低了其促进伤口愈合的能力,因此,FGF2的稳定性对其临床用于皮肤损伤修复尤为重要。本文就FGF2的分子结构及功能、FGF2受体激活的信号转导途径、FGF2在伤口愈合方面的作用机制及其在整形方面的应用作一综述。

Skin injury is one of the common diseases in clinic,which is mainly caused by acute trauma such as laceration,cut and contusion.Wound healing after skin injury is initiated immediately after trauma by releasing a variety of growth factors such as fibroblast growth factor 2(FGF2 or bFGF),platelet-derived growth factor(PDGF)and transforming growth factor-β(TGF-β).Some studies have shown that FGF2 may promote wound healing by promoting angiogenesis and granulation,reducing scar formation and accelerating epithelialization.However,because of the short half-life and the lower stabilization that susceptible to enzymatic and skin microenvironment in vivo,it only remains in the wound for a short time,and its ability to promote wound healing is also weakened.Therefore,it is particularly important to maintain the stability of FGF2 during wound healing.This paper reviews the molecular structure and function of FGF2,signaling pathway of activation of FGF2 receptor,action mechanism of FGF2 in would healing as well as application of FGF2 in plastic surgery.