基于“脾为谏议之官”理论探讨脾虚病机与胃癌前病变细胞焦亡的相关性

Correlation between spleen deficiency pathogenesis and pyroptosis in gastric precancerous lesions based on'spleen as remonstrator’theory

细胞焦亡是一种特殊性的细胞程序性死亡,作为胃癌“炎-癌链”发生发展中的重要一环,其在免疫方面功能与《黄帝内经》中提到的“脾为谏议之官”功能有一定相关性。文章基于“脾为谏议之官”理论,从“谏议之官”与脾藏意、主运化等功能的联系角度着手,结合现代医学对细胞焦亡的研究,分析脾虚病机与细胞焦亡之间的关联,为健脾类中药治疗脾虚型胃癌前病变的分子机制提供新思路。

Pyroptosis is a special type of programmed cell death. As an important part of the occurrence and development of gastric cancer ‘inflammatory-cancer chain’, its immune function is similar to the ‘spleen as remonstrator’ theory mentioned by Huangdi Neijing. Based on the ‘spleen as remonstrator’ theory, this article analyzed the relationship of the pathogenesis of spleen deficiency and imbalance of pyroptosis from the perspective of spleen stores yi and spleen’s function to transport and transform nutrients, combined with modern medicine research on cell pyrolysis. This association provides new ideas for the molecular mechanism level of spleen-strengthening herbs in treating gastric precancerous lesions of spleen deficiency type.