摘要
褪黑素是一种神经内分泌激素,在动物体内主要由松果体合成和分泌,具有调节昼夜节律的重要作用,包括卵巢生物钟系统。褪黑素在外周组织器官如女性生殖器官卵巢中也发挥重要生理作用。女性生殖过程中,卵泡不断产生并累积活性氧,进而造成组织细胞损伤。褪黑素可通过受体依赖或者受体非依赖的机制参与卵巢功能调节。最近研究发现,褪黑素还可通过调节细胞自噬机制发挥效应。该文就褪黑素对卵巢的保护作用及其相关机制的研究进展进行综述。
Melatonin is a neuroendocrine hormone that mainly synthesized and secreted by the pineal gland.It is known to regulate circadian rhythms of many biological and reproductive functions and exerts physiological roles in various peripheral organs including ovary.ROS (reactive oxygen species) are produced within the ovarian follicles during reproductive processes.Melatonin,is implicated in the regulation of reproductive physiology through receptor-dependent and receptor-independent mechanisms.Recent studies focus on the essential role of melatonin in the regulation of autophagy.This review summarizes new findings related to beneficial effects of melatonin on the ovarian function and the mechanisms of melatonin on the ovarian follicles.
作者
范艺辉
赖东梅
FAN Yihui;LAI Dongmei(The International Peace Maternity and Child Health Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Key Laboratory of Embryo Original Diseases,Shanghai Municipal Key Clinical Speciality,Shanghai 200030,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2020年第3期525-533,共9页
Chinese Journal of Cell Biology
基金
国家重点研发计划(批准号:2018YFC1004800、2018YFC1004802)资助的课题。
关键词
褪黑素
氧化应激
自噬
卵巢功能
melatonin
oxidative stress
autophagy
ovarian function
