长链非编码RNA在鼻咽癌转移机制中的研究进展

Progress of Long Noncoding RNA in the Metastasis Mechanism of Human Nasopharyngeal Carcinoma

鼻咽癌是头颈肿瘤中较常见且侵袭性较强的肿瘤。随着放化疗及分子靶向等综合治疗的发展,鼻咽癌死亡率明显下降。早期患者预后较好,但中晚期及复发转移的患者预后仍较差。因此,全面了解鼻咽癌转移机制至关重要。目前长链非编码RNA(long noncoding RNA,LncRNA)在肿瘤中的研究较为热门,且越来越多的研究发现,LncRNA在鼻咽癌转移机制中起到重要作用,如细胞上皮间质转化、细胞外基质降解及微血管形成等。该文就LncRNA在鼻咽癌转移机制研究作一综述。

Nasopharyngeal carcinoma is the more common and aggressive head and neck tumor.With the development of comprehensive therapies such as chemoradiotherapy and molecular targeting therapy,the mortality rate of nasopharyngeal carcinoma has decreased significantly.The prognosis of patients in early stage is favourable,while the prognosis of patients in middle and late stage or with recurrence and metastasis is still poor.Therefore,it is important to understand the molecular mechanism of nasopharyngeal carcinoma metastasis fully.At present,LncRNA (long noncoding RNA) is popular in tumor researches.More and more studies have found that LncRNAs play an important role in the metastasis mechanism of nasopharyngeal carcinoma,including EMT (epithelial mesenchymal transformation),degradation of ECM (extracellular matrix) and microvascular formation.This article reviews the metastasis mechanism of LncRNAs in nasopharyngeal carcinoma.