成纤维细胞生长因子信号在骨损伤修复中的作用

Role of fibroblast growth factor signaling in bone injury repair

骨损伤是常见的骨外科疾病。许多复杂的骨缺损,如创伤性大块骨缺损等常导致骨折延迟愈合及骨不连,是临床治疗中的难题。组织工程方法的运用为骨不连等的治疗提供了新的契机。成纤维细胞生长因子(fibroblast growth factor, FGF)信号在骨骼发育过程中发挥重要作用。基于其家族成员在骨折愈合过程中的时空表达及相关基因工程小鼠的表型,FGF信号相关分子被认为是骨再生修复的重要调节分子。该文将对FGF信号在骨损伤修复中的作用及应用方面的研究进展做综述,以期为其临床应用提供借鉴与参考。

Bone injury is a common bone surgery disease. Many complex skeletal defects such as large traumatic bone defects may cause delayed bone healing and fracture nonunion, which remains a challenge in clinical practice. The application of tissue engineering therapy provides a new opportunity for the treatment of nonunion. Fibroblast growth factor signaling plays an important role in bone development. Based on the their spatio-temporal expression during fracture healing and the phenotypes of genetically modified mice, FGF signaling-related molecules are considered as important regulatory molecules for bone regeneration and repair. This review will summarize the current understanding of FGF signaling-related molecules in bone injury repair, providing reference for its clinical application.