新型丝胶组织工程生物材料的创新研发及其在创伤修复中的应用

Development and application of sericin biomaterials for wound repair and tissue regeneration

再生医学与创伤修复需要合适的组织工程修复材料。蚕丝是我国特有的生物资源之一,蚕丝的主要组分丝胶,因其生物医学价值未知而常被作为缫丝行业的废料丢弃。近期的研究发现,丝胶具有优良的细胞亲和性和低免疫原性,在神经、心肌、软骨、骨骼肌、皮肤的修复及肿瘤治疗中效果良好,是性能优越的再生修复材料。该文简述了丝胶的组成结构和提取方法,以及丝胶生物材料在组织工程及创伤修复中的各种应用,并探讨了丝胶组织工程产品未来的研发重点和发展方向。

One of the major challenges for tissue repair and regeneration is lack of suitable biomaterials. Silk is a special biomaterial that was originally from China. Sericin, the main component of silk, was traditionally considered as a waste product from silk industry and its value was underestimated and unexplored until the scientists studied and reported its value for tissue regeneration. In the article, we briefly described the structure of sericin, its extraction methods and properties. And then we introduced the various applications of sericin in tissue engineering and wound repair and discussed the future direction for sericin tissue engineering products.