睡眠呼吸暂停时间对血氧饱和度和心率的影响

Effect of sleep apnea time on blood oxygen saturation and heart rate

目的睡眠呼吸暂停综合征患者发生呼吸暂停时需要及时唤醒,何时唤醒患者需要更多的参考依据。为此,试验研究了睡眠呼吸暂停时间对血氧饱和度和心率的影响,提出通过实时监测血氧饱和度来辅助判断是否发生呼吸暂停。方法选择健康志愿者10例,其中男性3例,女性7例;年龄22~24岁,平均年龄21.7岁;体质量44~85 kg,平均体质量58.35 kg;体质量指数17.3~25.9 kg/m^2,平均体质量指数20.81 kg/m^2;身高155~187 cm,平均身高166.1 cm。受试者通过憋气模拟呼吸暂停事件,利用AFE4490集成模拟前端采集受试者指端脉搏信号,并根据光电容积脉搏波波形计算血氧饱和度和心率值,得到了血氧饱和度和心率随呼吸暂停时长变化的特性曲线。结果血氧饱和度随呼吸暂停时间的增加呈下降趋势;心率随呼吸暂停时间的增加呈上升趋势。血氧饱和度首次代偿到达峰值的时间约为11.2 s,首次代偿结束时间约为18.6 s;心率首次代偿到达峰值的时间约为12.1 s,首次代偿结束时间约为19.4 s。结论患者发生呼吸暂停时,血氧饱和度和心率会出现周期性变化趋势,但与心率相比,血氧饱和度对呼吸暂停时长的变化更为敏感且规律。根据血氧饱和度随呼吸暂停的时间参数为睡眠呼吸暂停综合征患者的唤醒时刻提供了参考数据。

Objective To study the effect of sleep apnea time on blood oxygen saturation and heart rate, and monitor blood oxygen saturation in real time for auxiliary judgment in determining apnea occurs, in the consideration the reference basis for patients with sleep apnea syndrome who need to wake up in time during apnea. Methods Ten healthy volunteers were enrolled, which included 3 males and 7 females, aged 22-24 years old with mean age of 21.7 years old;body weight was 44-85 kg with mean body weight of 58.35 kg;body mass index was 17.3-25.9 kg/m^2 with mean body mass index of 20.81 kg/m^2;height was 155-187 cm with mean height of 166.1 cm. All of them simulated apnea by belching, and the fingertip pulse signals were collected using AFE4490 integrated simulation front-end, the blood oxygen saturation and heart rate were calculated based on the photoelectric volume pulse wave waveform, and the characteristic curves of blood oxygen saturation and heart rate as a function of apnea duration were obtained. Results As apnea time was increased, blood oxygen saturation decreased and heart rate increased. The peak time of the first compensation of blood oxygen saturation was about 11.2 seconds, and ending time of first compensation was about 18.6 seconds;peak time of the first compensation of heart rate was about 12.1 seconds,and ending time of the first compensation was 19.4 seconds. Conclusion It is demonstrated that the blood oxygen saturation and heart rate change periodically in apnea. Compared with heart rate, blood oxygen saturation is more sensitive and regular in apnea. The parameters of blood oxygen saturation and time parameters of apnea provide reference data for the awaking time of patients with sleep apnea syndrome.