精子尾部发育相关蛋白研究进展

Research progress of proteins related to sperm tail development

精子尾部结构与其运动功能密切相关。精子的运动能力直接决定了精子能否正常运输到输卵管与卵子受精。精子尾部的形成和发育是一个极其复杂的过程,由多种蛋白质精细调控。研究发现,多种精子尾部发育相关蛋白的缺陷可导致少、弱、畸形精子症。本文根据精子尾部的超微结构顺序,对近年来精子尾部发育相关蛋白的研究进展进行综述,以期为男性不育症的遗传学诊断和治疗提供理论基础和实践的可能。

The structure of sperm tail is closely related to its motor function,which directly determines whether the sperm can be normally transported to fallopian tube and fertilize the ovum.The formation and development of sperm tail is a very complex process,which is finely regulated by various kinds of proteins.Research finds that defects of various sperm tail development related proteins can lead to oligospermia,asthenozoospermia and teratospermia.Based on the ultrastructure of sperm tail,we summarize the recent research progress of the proteins related to sperm tail development,thereby providing the theoretical basis and practical possibility for the diagnosis and treatment of male infertility.