3,4-二甲基-5-苯基-1,3-噁唑烷检验

Verifi cation of 3,4-Dimethyl-5-phenyl-1,3-oxazolidine from a Case

在一起案件中,嫌疑人使用麻黄碱合成了一种未知的物质。使用气相色谱-质谱联用仪检验,未知物质的保留时间与麻黄碱的保留时间相近,其分子量为177个原子质量单位。随后的文献检索表明,麻黄碱能与醛类化合物反应生成噁唑烷。因此,未知物比麻黄碱多12个原子质量单位可以由麻黄碱与甲醛的缩合来解释。通过使用麻黄碱标准品和甲醛合成加合物,气相色谱质谱联用仪分析后,合成的加合物与样品中的未知物质保留时间匹配,质谱图与未知物质的质谱图匹配,证实嫌疑人合成的是3,4-二甲基-5-苯基-1,3-噁唑烷。

One unknown substance,seized from a case,was suspected of synthetic from ephedrine.Under identical gas chromatographic conditions,the substance showed the same retention time as that of ephedrine,yet different for their mass spectra,thereby indicating its actual molar mass of 177 amu.As suggested by the literature searched,ephedrine can react with aldehyde to produce oxazolidine.Thus,the more 12 amu of molar mass of the unknown compound than ephedrine can be potentially accounted for addition of a carbon atom into the ephedrine that had reacted with formaldehyde.Through synthesis of 3,4-dimethyl-5-phenyl-l,3-oxazolidine with standard ephedrine and formaldehyde,GC-MS was used to analyze both the newly-synthesized compound and that unknown substance from case,revealing same retention time from the two analyzed compounds together with their spectra being well-matched.Therefore,the unknown compound from case was confi rmed to be 3,4-dimethyl-5-phenyl-1,3-oxazolidine.