血小板在肝细胞癌诊断及预后评估中的应用

Application of platelet in diagnostic and prognostic evaluation of hepatocellular carcinoma

肝脏的病理生理状态可以直接或间接地导致血小板的形态学或生化异常。相反,在病理生物学方面,血小板也能够调节肝脏的促有丝分裂和促纤维化。血小板对肝脏的作用通常是由血小板衍生的生长因子促进的,而这些生长因子根据肝脏疾病或损伤的阶段和类型得以释放。因此,血小板蕴藏着临床相关信息,对肝脏疾病具有潜在的诊断和预后意义。本文总结了将血小板作为肝细胞癌诊断和预后工具的进展;还剖析了早期研究的相互矛盾的结果,并反映了如何结合基于血小板的信息为肝细胞癌的诊断和预后评估提供更可靠的检测手段。

The pathophysiological state of the liver can directly or indirectly impose morphological or biochemical abnormalities of the platelets.Inversely,platelets can also regulate its mitosis and fibrosis in liver pathobiology.The act of platelets on the liver is typically promoted by platelet-derived growth factors,which are released according to the stage and type of liver disease or injury.Therefore,platelets contain clinical related information with potential diagnostic and prognostic implications in liver diseases.This article summarized the progress of platelet as a diagnostic and prognostic tool for hepatocellular carcinoma.It also analyzed the contradictory results of earlier studies,and reflected how to combine platelet-based information to provide a more reliable detection for the diagnosis and prognosis of hepatocellular carcinoma.