表观遗传修饰在自身免疫性甲状腺疾病发病中的作用

The role of epigenetic modification in the pathogenesis of autoimmune thyroid disease

表观遗传修饰主要包括DNA甲基化、组蛋白修饰(乙酰化、甲基化、磷酸化、泛素化等)以及非编码RNAs作用等,它可以在不改变DNA序列的情况下影响基因转录活性。这些修饰对染色体结构的稳定性及基因的表达可能会有一定的影响。近年来越来越多的研究表明,表观遗传修饰在自身免疫性甲状腺疾病(Graves病和桥本甲状腺炎)的发病机制中发挥重要作用,这为自身免疫性甲状腺疾病的发病机制打开一个新的视角。进一步深入探索表观遗传修饰在自身免疫性甲状腺疾病发病中的作用,可以为该疾病的诊疗提供新的研究策略和思路。

Epigenetic modifications regulates gene expression without changing DNA sequences in some different ways,which include DNA methylation,histone modifications involving methylation,acetylation,phosphorylation,ubiquitylation,and non-coding RNAs.Each modification may influence the structure of chromatin and gene expression.In recent years,more and more researches show that epigenetic modifications play important roles in the pathogenesis of autoimmune thyroid diseases(Graves′disease,Hashimoto′s thyroiditis),which opens a new perspective for the pathogenesis of autoimmune thyroid diseases.Further studies are needed to explore the action of epigenetic modifications on the onset of autoimmune thyroid disease which will provide new research strategies for the diagnosis and treatment of autoimmune thyroid disease.