肠道菌群与自身免疫性甲状腺疾病

Gut Microbiota Gut microbiota and autoimmune thyroid disease

肠道菌群不仅维持消化系统平衡,对免疫、激素和代谢稳态也至关重要。自身免疫性甲状腺疾病(AITD)是内分泌系统最常见的自身免疫性疾病,由桥本甲状腺炎和Graves病等一系列疾病组成。近期研究发现,AITD患者肠道菌群与健康人群相比存在差异。肠道菌群可能通过影响甲状腺激素的代谢及激发机体交叉免疫反应,参与AITD的发生、发展。

Intestinal flora not only maintains the balance of the digestive system,but also is important for immune,hormones and metabolic homeostasis.Autoimmune thyroid disease(AITD)is the most common autoimmune disease in the endocrine system.It consists of a series of diseases such as Hashimoto′s thyroiditis and Graves′s disease.Recent studies have found that the intestinal flora between patients with AITD and healthy people is different.The intestinal flora may participate in the pathogenesis of AITD by affecting the the metabolism of thyroid hormones and stimulating cross immunity.