YAP、Claudin与肺癌干细胞

YAP and Claudin Related to Lung Cancer Stem Cell

肺癌干细胞(lung cancer stem cell,LCSC)是指来源于肺癌的一部分细胞群,具有自我更新能力,并影响肺癌发生发展及预后。Yes相关蛋白(Yes-associated protein,YAP)作为活化Hippo途径的关键转录蛋白在调节器官大小、细胞自我更新、干细胞特性等方面发挥重要作用。闭合蛋白(claudin,Cldn)是一种紧密连接骨架蛋白,作为YAP的调节剂,在癌症中经常功能失调。该文将对Cldn、YAP及肺癌干细胞间的相互关系进行综述。

Lung cancer stem cell refers to a cell population derived from lung cancer with the ability to self-renew,and it will affect the development and prognosis of lung cancer.YAP is a key transcriptional regulatory protein that activates the Hippo pathway and plays an important role in regulating organ size,cell self-renewal and stem cell characteristics.Cldn(claudin)is an integral tight junction protein that acts as a modulator of YAP and is often dysfunctional in cancer.In this paper,the relationship between Cldn,YAP and LCSC will be reviewed.