鞘内注射甲泼尼龙对不完全脊髓损伤康复的疗效分析

Efficacy of the intrathecal injection of methylprednisolone in the rehabilitation of incomplete spinal cord injury

目的:探讨蛛网膜下腔注射甲泼尼龙后对脊髓损伤后康复效果的影响。方法:选取颈脊髓损伤后不完全截瘫行康复治疗的病人131例,随机分为观察组68例和对照组63例。2组病人均接受普通康复治疗。观察组在普通康复治疗基础上,接受蛛网膜下腔注射甲泼尼龙治疗。治疗前后按美国脊髓损伤协会(ASIA)标准对2组病人进行评估。结果:治疗前2组病人ASIA评分差异无统计学意义(P>0.05)。治疗后8周,2组ASIA评分均明显高于治疗前(P<0.01),且观察组评分明显高于对照组(P<0.01)。结论:甲泼尼龙鞘内注射有助于提高脊髓损伤病人的康复疗效。

Objective:To observe the effects of intrathecal injection of methylprednisolone in the rehabilitation of incomplete spinal cord injury.Methods:One hundred and thirty-one incomplete paraplegia patients with spinal cord injury were randomly divided into the observation group(68 cases)and control group(63 cases).Two groups were treated with the common rehabilitation method,and the observation group was additionally treated with intrathecal injection of methylprednisolone.Two groups were evaluated before and after treatment according to the American Spinal Injury Association(ASIA)criteria.Results:There was no statistical significance in ASIA score between two groups before treatment(P>0.05).After 8 weeks of treatment,the ASIA scores in two groups were significantly higher than that before treatment(P<0.01),and the scores in observation group were significantly higher than those in the control group(P<0.01).Conclusions:The intrathecal injection of methylprednisolone can significantly improve the postoperative rehabilitation effects in patients with spinal cord injury.