摘要
目的探讨睡眠时间与初发缺血性脑卒中发病的关系。方法选取初次发作的缺血性脑卒中病人320例作为病例组,同期健康查体中心健康查体者279例作为对照组。采用统一调查问卷进行睡眠时间及其他影响因素调查和数据采集。采用χ^2检验、独立样本t检验及二分类Logistic回归统计方法分析睡眠时间与初发缺血性脑卒中发病的关系。结果病例组与对照组睡眠时间以及性别、年龄、体质指数、学历、吸烟、饮酒、饮茶、饮食、兴趣爱好、高血压、糖尿病、高脂血症及心血管疾病等相比较,差异均有统计学意义(χ^2=4.385~93.076,t=7.268,P<0.05)。调整上述因素后,多因素Logistic回归分析显示,与睡眠时间7~8 h相比,睡眠时间≤6 h(OR=2.451,95%CI=1.431~4.199,P<0.01)、睡眠时间≥9 h(OR=3.031,95%CI=1.001~9.367,P<0.05)均为初发缺血性脑卒中的危险因素,而6 h<睡眠时间<7 h为缺血性脑卒中的保护因素(OR=0.199,95%CI=0.043~0.912,P<0.05)。结论睡眠时间过短或过长均可增加初发缺血性脑卒中的发生风险,而6 h<睡眠时间<7 h可减少初发缺血性脑卒中的发生风险。
Objective To analyze the relationship between sleep duration and the development of primary ischemic stroke.Methods A total of 320 patients with first attack of ischemic stroke were selected as case group,and 279 healthy subjects who underwent physical examination at the physical examination center during the same period were selected as control group.A uniform questionnaire was adopted to investigate the sleep duration and other influencing factors and collect data.The chi-square test,independent samples t-test,and binary Logistic regression analysis were used to analyze the relationship between sleep duration and the development of primary ischemic stroke.Results There were significant differences in sleep duration,sex,age,body mass index,education background,smoking,drinking,tea drinking,diet,hobbies,hypertension,diabetes,hyperlipidemia,and cardiovascular diseases between the case group and the control group(χ^2=4.385-93.076,t=7.268,P<0.05).After adjusting the above factors,multivariate Logistic regression analysis showed that compared with a sleep duration of 7-8 h,sleep duration≤6 h(OR=2.451,95%CI=1.431-4.199,P<0.01)and sleep duration≥9 h(OR=3.031,95%CI=1.001-9.367,P<0.05)were both risk factors for primary ischemic stroke,while 6 h<sleep duration<7 h was a protective factor(OR=0.199,95%CI=0.043-0.912,P<0.05).Conclusion Too short or too long sleep duration can increase the risk of primary ischemic stroke,while 6 h<sleep duration<7 h can reduce the risk of primary ischemic stroke.
作者
张俊青
魏亚琳
谭巧文
彭琳
邓志莹
郭宗君
ZHANG Junqing;WEI Yalin;TAN Qiaowen;PENG Lin;DENG Zhiying;GUO Zongjun(Department of Geriatrics, Affiliated Hospital of Qingdao University, Qingdao 266003, China)
出处
《青岛大学学报(医学版)》
CAS
2020年第3期289-292,共4页
Journal of Qingdao University(Medical Sciences)
基金
山东省自然科学基金资助项目(ZR2012HM049)。
关键词
脑缺血
卒中
睡眠
时间因素
影响因素分析
brain ischemia
stroke
sleep
time factors
root cause analysis