产褥期女性阴道微生态分析

Analysis of vaginal microgenesis in women during puerperium

目的探讨产褥期女性阴道微生态的变化,为临床预防和控制产妇阴道菌群失衡提供参考依据。方法回顾性分析2018年1月至2018年12月在医院妇科门诊就诊的产后6~8周复查产妇共1000例作为研究组,选取同期参加体检的正常非妊娠妇女1000名作为对照组。采用阴道微生态评价体系进行微生态评价。结果研究组的优势菌主要为菌群抑制状态,占比58.40%,对照组主要为革兰阳性杆菌,占比77.20%,两组比较差异有统计学意义(X^2=1499.89,P<0.001);研究组菌群密集度主要为未见细菌状态,占比58.40%,对照组主要为Ⅲ级,占比73.40%,两组比较差异有统计学意义(X^2=1582.39,P<0.001);研究组菌群多样性主要为未见细菌状态,占比58.40%,对照组主要为Ⅱ级,占比82.40%,两组比较差异有统计学意义(X^2=1389.13,P<0.001);研究组Nugengt评分中,中间型占的比例最大,占比74.80%,对照组以0~3分比例最大,为73.70%(737/1000),两组比较差异有统计学意义(X^2=778.63,P<0.001);研究组AV评分中,5~6分占的比例最大,占比72.40%,对照组以<3分比例最大,占比75.30%,两组比较差异有统计学意义(X^2=1248.94,P<0.001)。结论产褥期女性阴道微生态失衡较多,临床医生及处于这一时期的女性应引起高度重视。

Objective To explore the changes of female reproductive tract microecology during puerperium,and to provide reference for clinical prevention and control of maternal flora imbalance.Methods Retrospective analysis of a total of 1000 cases of maternal review in the postpartum period of 6-8 weeks from January 2018 to December 2018 in the gynecology clinic of the hospital as research group.The control group included 1000 normal non-pregnant women who attended the physical examination during the same period.Vaginal microecological evaluation system was adopted for microecological evaluation.Results The dominant bacteria in the research group were mainly flora inhibition,accounting for 58.40%,and the control group was mainly Gram-positive Bacillus,accounting for 77.20%,the difference between the two groups was statistically significant(X^2=1499.89,P<0.001).The concentration of bacteria in the study group was mainly no bacterial state,accounting for 58.40%,and the control group was mainlyⅢ,accounting for 73.40%.The difference between the two groups was statistically significant(X^2=1582.39,P<0.001).The diversity of flora in the study group was mainly no bacterial status,accounting for 58.40%,and the control group was mainlyⅡ,accounting for 82.40%.The difference between the two groups was statistically significant(X^2=1389.13,P<0.001).In the Nugengt score of the study group,the middle type accounted for the largest proportion 74.80%,and the control group had the highest ratio of 0-3 points,which was 73.70%.The difference between the two groups was statistically significant(X^2=778.63,P<0.001).In the AV score of the research group,5-6 scored the most,with 72.40%,and the control group had the largest proportion of 3 scores,accounting for 75.30%.The difference between the two groups was statistically significant(X^2=1248.94,P<0.001).Conclusion The female vagina microecological imbalance is more in the puerperium period,and clinicians and women in this period should be highly valued.